Endocrine Pharmacology USMLE Step 1 Practice Questions
100 board-style USMLE Step 1 questions in Pharmacology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · easy49. A 19-year-old man with type 1 diabetes mellitus presents to the emergency department with abdominal pain, vomiting, and confusion. He has not taken insulin in 48 hours. Vital si…
- USMLE Step 1 · easy50. A 27-year-old woman with a 12-year history of type 1 diabetes mellitus presents to her endocrinologist for a routine follow-up. She currently uses a basal bolus insulin regimen…
- USMLE Step 1 · hard51. A 52-year-old woman with type 2 diabetes mellitus presents with an HbA1c of 8.2% despite metformin 1000 mg twice daily for six months. She is hypertensive (BP 148/92 mmHg, HR 88…
- USMLE Step 1 · medium52. A 67-year-old man with type 2 diabetes mellitus and hypertension recently started a new antidiabetic agent. He presents with orthostatic lightheadedness, 3-kg weight loss, and r…
- USMLE Step 1 · hard53. A 74-year-old man with type 2 diabetes mellitus, severe peripheral vascular disease, and stage 4 chronic kidney disease (eGFR 18 mL/min/1.73m²) presents for medication adjustmen…
- USMLE Step 1 · hard54. A 49-year-old woman with acromegaly treated with somatostatin analogs has experienced significant improvement in headaches and soft tissue swelling. Six months into therapy, she…
- USMLE Step 1 · hard55. A 17-year-old boy with mild hemophilia A presents for dental extraction. Vital signs are stable: BP 120/78 mmHg, HR 82/min, RR 16/min, temp 37°C. Laboratory studies show factor…
- USMLE Step 1 · medium56. A 54-year-old postmenopausal woman with estrogen receptor-positive breast cancer has been taking tamoxifen 20 mg daily for 2 years. She presents with vaginal bleeding and mild l…
- USMLE Step 1 · medium57. A 25-year-old woman at 6 weeks gestation presents requesting medical abortion. Vital signs are stable (BP 118/76, HR 82, RR 16, Temp 37.0°C). She receives a progesterone recepto…
- USMLE Step 1 · medium58. A 38-year-old woman with a 15-year smoking history (1 pack daily) and migraine with aura presents requesting oral contraception. She reports migraines occurring twice monthly, e…
- USMLE Step 1 · medium59. A 72-year-old man with a 3-year history of metastatic prostate cancer presents to his oncology clinic for routine follow-up. His blood pressure is 128/76 mmHg, heart rate is 82/…
- USMLE Step 1 · hard60. A 57-year-old man with primary hyperaldosteronism (plasma aldosterone 28 ng/dL, suppressed renin) presenting with hypertension (BP 162/98 mmHg) and hypokalemia (K+ 3.1 mEq/L) st…
- USMLE Step 1 · medium61. A 23-year-old woman with severe hirsutism, acne, and irregular menses presents with clinical hyperandrogenism. She is started on a medication that antagonizes aldosterone recept…
- USMLE Step 1 · easy62. A 71-year-old man with benign prostatic hyperplasia presents with urinary hesitancy, weak stream, and nocturia. Vital signs are stable (BP 142/88, HR 78, RR 16). Post-void resid…
- USMLE Step 1 · medium63. A 29-year-old woman with a 2-year history of infertility due to anovulation presents wanting to conceive. Vital signs are stable (BP 118/76, HR 78, RR 14, Temp 37°C). Serum FSH…
- USMLE Step 1 · medium64. A 68-year-old man with metastatic prostate adenocarcinoma (PSA 187 ng/mL) initiates continuous GnRH analog therapy. Vital signs are stable: BP 138/82, HR 76, RR 16, temp 37°C. T…
- USMLE Step 1 · medium65. A 55-year-old man with end-stage renal disease on hemodialysis three times weekly presents with BP 148/92, HR 88, RR 16, temp 37°C, and SpO2 98%. Laboratory studies reveal persi…
- USMLE Step 1 · medium66. A 62-year-old postmenopausal woman with osteoporosis presents with progressive lumbar back pain for three months. Her blood pressure is 118/74 mmHg and BMI is 23 kg/m². BMD T-sc…
- USMLE Step 1 · medium67. A 74-year-old woman with stage 3b chronic kidney disease and osteoporosis presents with BP 138/82 mmHg, HR 78/min, afebrile. She was previously on alendronate but experiences pe…
- USMLE Step 1 · easy68. A 69-year-old postmenopausal woman with osteoporosis presents with BP 138/82, HR 78, RR 16, afebrile, SpO2 98% on room air. Recent DEXA scan shows T-score of -2.8 at the femoral…
- USMLE Step 1 · medium69. A 73-year-old woman with severe osteoporosis presents with acute back pain. Vital signs: BP 138/82, HR 88, RR 16, Temp 37.2°C, SpO2 98% on room air. She has sustained three vert…
- USMLE Step 1 · easy70. A 28-year-old woman develops severe postpartum hemorrhage secondary to uterine atony 30 minutes after vaginal delivery. Vital signs show BP 95/58, HR 118, RR 20, and hemoglobin…
- USMLE Step 1 · medium71. A 70-year-old man with small cell lung carcinoma presents with severe headache and confusion. Vital signs show BP 128/76 mmHg, HR 88/min, RR 16/min, temperature 37.2°C. Laborato…
- USMLE Step 1 · medium72. A 14-year-old boy presents with polyuria and polydipsia following a traumatic brain injury. Vital signs show HR 88/min, BP 118/76 mmHg, RR 16/min. Serum sodium is 148 mEq/L; uri…