Endocrine Pharmacology USMLE Step 1 Practice Question
A 57-year-old man with primary hyperaldosteronism (plasma aldosterone 28 ng/dL, suppressed renin) presenting with hypertension (BP 162/98 mmHg) and hypokalemia (K+ 3.1 mEq/L) started spironolactone therapy. He develops painful gynecomastia within 6 weeks. His physician switches to a related aldosterone antagonist with minimal antiandrogen activity. The patient denies breast tenderness after the medication change. Which drug was most likely prescribed?
Answer choices
- AHydrocortisone
- BFlutamide
- CFinasteride
- DEplerenoneCorrect answer
- ESpironolactone
- FAmiloride
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