Endocrine Pharmacology USMLE Step 1 Practice Questions
100 board-style USMLE Step 1 questions in Pharmacology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 52-year-old woman with type 2 diabetes mellitus presents with a fasting blood glucose of 187 mg/dL, BP 128/82 mmHg, HR 78/min, and BMI 31 kg/m². Her recent HbA1c is 8.2% despi…
- USMLE Step 1 · medium2. A 67-year-old man with type 2 diabetes mellitus and hypertension starts a new antidiabetic medication. He presents with orthostatic lightheadedness, 3-kg weight loss, and recurr…
- USMLE Step 1 · hard3. A 74-year-old man with type 2 diabetes mellitus, severe peripheral vascular disease, and stage 4 chronic kidney disease (eGFR 18 mL/min/1.73m²) presents for medication adjustmen…
- USMLE Step 1 · hard4. A 49-year-old woman with acromegaly treated with somatostatin analog therapy demonstrates improved headaches and soft tissue swelling. Six months into treatment, she presents wi…
- USMLE Step 1 · hard5. A 17-year-old boy with mild hemophilia A presents for elective dental extraction. His hematologist administers an intranasal medication to increase von Willebrand factor and fac…
- USMLE Step 1 · medium6. A 54-year-old postmenopausal woman with estrogen receptor-positive breast cancer was started on tamoxifen 2 years ago. She now presents with vaginal bleeding (BP 128/82, HR 82,…
- USMLE Step 1 · medium7. A 25-year-old woman at 7 weeks gestation by last menstrual period presents to an outpatient clinic requesting medical termination of pregnancy. She has a confirmed intrauterine…
- USMLE Step 1 · medium8. A 38-year-old woman with a history of migraine with aura and a one pack-per-day smoking history for the past 12 years presents to her gynecologist requesting oral contraception…
- USMLE Step 1 · medium9. A 72-year-old man with metastatic prostate cancer presents with BP 138/82, HR 88, RR 16, temperature 37.2°C, and SpO2 98% on room air. He reports gynecomastia and decreased libi…
- USMLE Step 1 · hard10. A 57-year-old man with primary hyperaldosteronism presenting with hypertension (BP 168/98 mmHg), hyperkalemia (K+ 5.8 mEq/L), and metabolic alkalosis develops painful gynecomast…
- USMLE Step 1 · medium11. A 23-year-old woman with a 2-year history of progressive hirsutism, moderate inflammatory acne, and irregular menstrual cycles occurring every 45–60 days presents to her gynecol…
- USMLE Step 1 · easy12. A 71-year-old man with benign prostatic hyperplasia presents with urinary hesitancy, weak stream, and nocturia occurring four times nightly. Vitals: BP 138/82, HR 78, RR 16, Tem…
- USMLE Step 1 · medium13. A 29-year-old woman with a 2-year history of infertility secondary to anovulation presents wanting to conceive. Vital signs: BP 118/76, HR 72, RR 14, Temp 98.6°F, SpO2 98%. Seru…
- USMLE Step 1 · medium14. A 68-year-old man with a 3-year history of metastatic prostate adenocarcinoma presents to his oncology clinic for follow-up after recent bone scan revealing new lytic lesions in…
- USMLE Step 1 · medium15. A 55-year-old man on hemodialysis presents with persistent hyperparathyroidism. Vital signs show BP 148/92 mmHg, HR 88 bpm, RR 16, temp 37°C. Labs reveal PTH 487 pg/mL (normal <…
- USMLE Step 1 · medium16. A 62-year-old postmenopausal woman with osteoporosis presents with progressive lower back pain for three months. Vital signs: BP 128/76, HR 78, RR 16, Temp 37°C, SpO2 98%. Recen…
- USMLE Step 1 · medium17. A 74-year-old woman with osteoporosis and chronic kidney disease (eGFR 35 mL/min/1.73m²) presents with worsening lower back pain for three weeks. Vital signs: BP 138/82, HR 78,…
- USMLE Step 1 · easy18. A 69-year-old postmenopausal woman with osteoporosis (T-score −2.8 on DEXA scan) and a serum calcium of 9.4 mg/dL presents with BP 128/76, HR 72, RR 14, and normal temperature.…
- USMLE Step 1 · medium19. A 73-year-old woman with severe osteoporosis presents with multiple vertebral compression fractures despite adequate calcium and vitamin D supplementation. Vital signs: BP 138/8…
- USMLE Step 1 · easy20. A 28-year-old woman develops postpartum hemorrhage secondary to uterine atony following vaginal delivery. Vital signs show BP 98/62, HR 118, RR 20, temperature 37.2°C. Hemoglobi…
- USMLE Step 1 · medium21. A 70-year-old man with small cell lung carcinoma presents with headache and confusion. Vital signs show BP 128/76 mmHg, HR 82/min, RR 16/min, temperature 37.2°C. Laboratory stud…
- USMLE Step 1 · medium22. A 14-year-old boy presents with polyuria and polydipsia following a traumatic brain injury sustained in a motor vehicle accident three days ago. Vital signs show HR 92 bpm, BP 1…
- USMLE Step 1 · easy23. A 28-year-old woman presents to her gynecologist with a 6-month history of amenorrhea, bilateral milky nipple discharge, and inability to conceive despite 12 months of unprotect…
- USMLE Step 1 · hard24. A 51-year-old man with acromegaly treated with transsphenoidal surgery presents with persistent symptoms. Vital signs: BP 148/92, HR 88, RR 16, Temp 98.6°F, SpO2 98%. Laboratory…