Endocrine Pharmacology USMLE Step 1 Practice Question
A 71-year-old man with benign prostatic hyperplasia presents with urinary hesitancy, weak stream, and nocturia occurring four times nightly. Vitals: BP 138/82, HR 78, RR 16, Temp 37°C. PSA is 8.2 ng/mL with prostate volume 45 mL on ultrasound. Digital rectal exam reveals a smooth, symmetrically enlarged prostate without nodules. He denies erectile dysfunction. He is prescribed an oral medication taken once daily that inhibits 5-alpha reductase, decreasing dihydrotestosterone conversion and gradually shrinking the prostate over several months. Which drug was most likely prescribed?
Answer choices
- ATamsulosin
- BLeuprolide
- CFlutamide
- DFinasterideCorrect answer
- ESpironolactone
- FDutasteride dual 5-alpha reductase inhibitor with broader DHT reduction
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