Endocrine Pharmacology USMLE Step 1 Practice Question
A 74-year-old woman with osteoporosis and chronic kidney disease (eGFR 35 mL/min/1.73m²) presents with worsening lower back pain for three weeks. Vital signs: BP 138/82, HR 78, RR 16, Temp 37°C, SpO2 98%. Recent DEXA scan shows a lumbar spine T-score of −2.8. Serum calcium is 9.1 mg/dL. She denies fever or focal neurologic symptoms. Physical exam reveals midline lumbar tenderness without paraspinal spasm. Previously taking oral bisphosphonate therapy, she is now switched to a monoclonal antibody that inhibits osteoclast activation by neutralizing RANK ligand. Which drug was prescribed?
Answer choices
- ATeriparatide
- BAlendronate
- CRaloxifene
- DDenosumabCorrect answer
- ECalcitonin
- FZoledronic acid
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