Endocrine Pharmacology USMLE Step 1 Practice Questions
100 board-style USMLE Step 1 questions in Pharmacology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium25. A 43-year-old man presents to his endocrinologist reporting progressive enlargement of his hands and feet over the past 4 years, requiring multiple ring and shoe size increases.…
- USMLE Step 1 · hard26. A 39-year-old woman with Cushing disease presents for pituitary ACTH reserve testing. Vital signs show BP 158/92 mmHg, HR 88, RR 16, temp 37°C. Physical examination reveals cent…
- USMLE Step 1 · hard27. A 37-year-old man with small cell lung carcinoma presents with ectopic ACTH syndrome. Vital signs show BP 168/98 mmHg, HR 102, RR 18, temp 37.2°C. Physical examination reveals c…
- USMLE Step 1 · medium28. A 24-year-old woman with autoimmune primary adrenal insufficiency treated with hydrocortisone monotherapy presents with orthostatic dizziness and salt craving. Vital signs show…
- USMLE Step 1 · medium29. A 45-year-old woman with central obesity, proximal muscle weakness, and easy bruising undergoes evaluation for Cushing syndrome. Vital signs show BP 158/92 mmHg, HR 88 bpm, RR 1…
- USMLE Step 1 · easy30. A 58-year-old woman with rheumatoid arthritis treated with daily oral glucocorticoids for 9 months presents with proximal muscle weakness, thin fragile skin, and easy bruising.…
- USMLE Step 1 · hard31. A 42-year-old woman with refractory Graves disease on propylthiouracil presents for preoperative optimization before scheduled thyroidectomy in 10 days. Vital signs: BP 142/88,…
- USMLE Step 1 · hard32. A 34-year-old woman with a known history of Graves disease who discontinued her methimazole three weeks ago is brought to the emergency department by her husband, who reports sh…
- USMLE Step 1 · medium33. A 31-year-old woman with Graves disease started antithyroid therapy 6 weeks ago. She now presents with fever (38.9°C), severe pharyngitis, and malaise. Vital signs show tachycar…
- USMLE Step 1 · medium34. A 26-year-old woman at 8 weeks' gestation presents with palpitations, heat intolerance, and weight loss. Vital signs show BP 138/82 mmHg, HR 108 bpm, RR 18/min, and temperature…
- USMLE Step 1 · medium35. A 35-year-old woman with Hashimoto thyroiditis started levothyroxine replacement 3 months ago but continues experiencing fatigue and constipation. Vital signs: BP 128/82, HR 58,…
- USMLE Step 1 · hard36. A 29-year-old woman with type 1 diabetes mellitus on mealtime insulin lispro presents with persistent postprandial glucose excursions peaking at 280 mg/dL despite carbohydrate c…
- USMLE Step 1 · medium37. A 64-year-old woman with a 9-year history of type 2 diabetes mellitus presents to her primary care physician for a routine follow-up. Her HbA1c is 7.8%, fasting plasma glucose i…
- USMLE Step 1 · easy38. A 57-year-old man with type 2 diabetes mellitus started a new oral agent two months ago. He now presents with polyuria, polydipsia, and recurrent candidal balanitis. Vital signs…
- USMLE Step 1 · medium39. A 66-year-old woman with type 2 diabetes mellitus presents with a fasting glucose of 156 mg/dL and HbA1c of 8.2%. She is overweight (BMI 31) and seeks an oral agent that increas…
- USMLE Step 1 · easy40. A 43-year-old woman with a 6-year history of obesity and type 2 diabetes mellitus presents to her primary care physician for a routine follow-up. Her current medications include…
- USMLE Step 1 · medium41. A 59-year-old woman with a 12-year history of type 2 diabetes mellitus and compensated systolic heart failure (ejection fraction 40%) presents to her primary care physician for…
- USMLE Step 1 · medium42. A 60-year-old man with type 2 diabetes mellitus presents with a fasting glucose of 110 mg/dL but postprandial glucose of 280 mg/dL due to irregular meal timing throughout the da…
- USMLE Step 1 · hard43. A 67-year-old man with type 2 diabetes mellitus presents with facial flushing, nausea, and palpitations 15 minutes after consuming wine at dinner. Vital signs show BP 145/92 mmH…
- USMLE Step 1 · easy44. A 55-year-old woman with type 2 diabetes mellitus presents with fatigue and polyuria. Vital signs: BP 138/82 mmHg, HR 88/min, RR 16/min, temperature 37°C, SpO2 98% on room air.…
- USMLE Step 1 · medium45. A 62-year-old woman with a 10-year history of type 2 diabetes mellitus comes to the clinic because of progressive fatigue, generalized weakness, and numbness of her feet over th…
- USMLE Step 1 · easy46. A 49-year-old obese man presents to his primary care physician for a routine follow-up after laboratory results revealed fasting glucose of 168 mg/dL and hemoglobin A1c of 8.0%…
- USMLE Step 1 · easy47. A 46-year-old woman with a 22-year history of type 1 diabetes mellitus presents to her endocrinologist for a routine follow-up, reporting episodes of nocturnal diaphoresis, palp…
- USMLE Step 1 · medium48. A 58-year-old man with a 12-year history of type 2 diabetes mellitus presents to his primary care physician reporting recurrent episodes of diaphoresis, tremulousness, and confu…