Endocrine Pharmacology USMLE Step 1 Practice Question
A 52-year-old woman with type 2 diabetes mellitus presents with a fasting blood glucose of 187 mg/dL, BP 128/82 mmHg, HR 78/min, and BMI 31 kg/mĀ². Her recent HbA1c is 8.2% despite metformin 1000 mg twice daily for six months. Creatinine is 0.9 mg/dL with an eGFR of 78 mL/min/1.73mĀ². She refuses injectable medications and expresses concern about further weight gain. Physical exam reveals mild truncal obesity without lower extremity edema. She denies polyuria or polydipsia. Which incretin-based medication best addresses her treatment goals while minimizing weight gain?
Answer choices
- ANPH insulin
- BPioglitazone
- CGlyburide
- DSitagliptinCorrect answer
- ESemaglutide
- FAcarbose
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