Endocrine Pharmacology USMLE Step 1 Practice Question
A 57-year-old man with primary hyperaldosteronism presenting with hypertension (BP 168/98 mmHg), hyperkalemia (K+ 5.8 mEq/L), and metabolic alkalosis develops painful gynecomastia after starting spironolactone. His physician switches him to a related potassium-sparing diuretic with much less antiandrogen activity but preserved aldosterone receptor blockade. Notably, he denies gynecomastia regression on current therapy. Which of the following drugs was most likely prescribed?
Answer choices
- AFlutamide
- BEplerenoneCorrect answer
- CFinasteride
- DHydrocortisone
- ESpironolactone
- FAmiloride
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