Endocrine Pharmacology USMLE Step 1 Practice Question
A 74-year-old woman with stage 3b chronic kidney disease and osteoporosis presents with BP 138/82 mmHg, HR 78/min, afebrile. She was previously on alendronate but experiences persistent GI intolerance. She is now switched to a subcutaneous monoclonal antibody that inhibits osteoclast activation by neutralizing RANK ligand. Recent bone density scan shows T-score of −2.8. Laboratory studies reveal normal serum calcium and phosphate. Which drug was most likely prescribed?
Answer choices
- ARaloxifene
- BAlendronate
- CDenosumabCorrect answer
- DTeriparatide
- ECalcitonin
- FRomosozumab
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.