Endocrine Pharmacology USMLE Step 1 Practice Question
A 72-year-old man with a 3-year history of metastatic prostate cancer presents to his oncology clinic for routine follow-up. His blood pressure is 128/76 mmHg, heart rate is 82/min, and respiratory rate is 16/min. Physical examination reveals no palpable gynecomastia or breast tenderness, and his testes are of normal size bilaterally. Urinalysis is within normal limits. His PSA is significantly elevated at 18 ng/mL, and repeat bone scan confirms osseous metastases. He reports no prior hormonal or androgen-deprivation therapy. His oncologist initiates a nonsteroidal antiandrogen agent that competitively blocks both testosterone and dihydrotestosterone at the androgen receptor level without suppressing central gonadotropin release. Which of the following drugs was most likely prescribed?
Answer choices
- AFinasteride
- BSpironolactone
- CFlutamideCorrect answer
- DClomiphene
- ELeuprolide
- FEnzalutamide
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