Endocrine Pharmacology USMLE Step 1 Practice Question
A 52-year-old woman with type 2 diabetes mellitus presents with an HbA1c of 8.2% despite metformin 1000 mg twice daily for six months. She is hypertensive (BP 148/92 mmHg, HR 88/min), overweight (BMI 31 kg/mĀ²), and her fasting glucose today is 184 mg/dL. She adamantly refuses injectable medications and expresses concern about iatrogenic weight gain. Physical examination reveals no peripheral edema. She denies polyuria, polydipsia, and recent infections. Which oral incretin-based medication best aligns with her clinical preferences and metabolic goals?
Answer choices
- ASemaglutide
- BNPH insulin
- CSitagliptinCorrect answer
- DGlyburide
- EPioglitazone
- FAcarbose
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