Organ System Pathology USMLE Step 1 Practice Questions
55 board-style USMLE Step 1 questions in Pathology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium25. A 48-year-old woman presents with progressive bilateral leg edema and dyspnea on exertion. Vital signs show BP 148/92 mmHg, HR 88/min, RR 18/min, temp 37°C, SpO2 98% on room air…
- USMLE Step 1 · medium26. A 36-year-old man with HIV presents with progressive lower extremity edema and dyspnea. Vital signs: BP 128/82 mmHg, HR 98/min, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Lab…
- USMLE Step 1 · easy27. A 4-year-old boy presents with periorbital and ankle edema. Vital signs show BP 105/68 mmHg, HR 98 bpm, RR 22/min, temp 37.2°C, SpO2 98% on room air. Urinalysis reveals 4+ prote…
- USMLE Step 1 · medium28. A 19-year-old college student presents with gross hematuria one day after acute pharyngitis onset. He reports three similar episodes over 2 years, each resolving spontaneously w…
- USMLE Step 1 · medium29. A 7-year-old girl presents with dark urine and facial puffiness two weeks after impetigo on her legs. Vital signs show BP 128/82 mmHg, HR 88 bpm, RR 20/min, temperature 37.2°C,…
- USMLE Step 1 · easy30. A 10-year-old boy presents with cola-colored urine and periorbital edema 2 weeks after streptococcal pharyngitis. Vital signs show BP 148/92 mmHg (elevated for age), HR 88/min,…
- USMLE Step 1 · easy31. A 7-month-old infant presents with episodes of cyanosis worsening during feeding and crying. Parents note the infant instinctively assumes a squatting position during play. Vita…
- USMLE Step 1 · easy32. A premature newborn (32 weeks gestation) presents with tachypnea (RR 68/min), poor weight gain, and feeding intolerance. Vital signs show BP 55/35 mmHg, HR 165/min, SpO2 98% on…
- USMLE Step 1 · easy33. A 2 month old boy is brought in for poor feeding and tachypnea. Examination reveals a harsh holosystolic murmur best heard at the left lower sternal border. Echocardiography sho…
- USMLE Step 1 · hard34. A 31-year-old woman with photosensitive malar rash, recurrent oral ulcers, and polyarthralgias presents with dyspnea on exertion. Vital signs: BP 128/82, HR 98, RR 18, Temp 37.2…
- USMLE Step 1 · medium35. A 50 year old man with poor dentition presents with fever, malaise, and a new heart murmur 2 weeks after a dental extraction. Blood cultures grow alpha hemolytic gram positive c…
- USMLE Step 1 · easy36. A 27-year-old woman presents with intermittent palpitations and atypical chest pain. Vital signs: BP 118/76 mmHg, HR 88 bpm, RR 16/min, temp 37°C, SpO2 98% on room air. Cardiac…
- USMLE Step 1 · easy37. A 42 year old woman presents with progressive exertional dyspnea and intermittent hemoptysis. She emigrated from an area where streptococcal infections were common and reports r…
- USMLE Step 1 · medium38. A 67 year old man is hospitalized for an acute transmural myocardial infarction. Two days later, he develops sudden pulmonary edema and hypotension. Examination shows a new holo…
- USMLE Step 1 · easy39. A 48 year old man presents with palpitations and awareness of a forceful heartbeat. He recently recovered from infective endocarditis. Blood pressure is 162/54 mm Hg. Examinatio…
- USMLE Step 1 · easy40. A 76 year old man presents with several months of exertional chest pain and two episodes of near syncope while climbing stairs. He has a history of hyperlipidemia and smoking. B…
- USMLE Step 1 · medium41. A 19-year-old college student presents to the emergency department with fever (39.8°C), hypotension (82/54 mmHg), tachycardia (128 bpm), and tachypnea (22 bpm). A rapidly progre…
- USMLE Step 1 · easy42. A 38-year-old woman presents with progressive fatigue, unintentional weight loss, and orthostatic dizziness. She reports intense salt cravings. Vital signs show BP 92/58 mmHg, H…
- USMLE Step 1 · medium43. A 46 year old woman has central obesity, purple abdominal striae, and glucose intolerance. ACTH is low, and serum cortisol is elevated with no suppression after low or high dose…
- USMLE Step 1 · medium44. A 63 year old man with a 50 pack year smoking history has new hypertension, proximal weakness, and hyperglycemia. Examination shows thin skin and diffuse hyperpigmentation. Seru…
- USMLE Step 1 · hard45. A 35 year old woman presents with weight gain, proximal muscle weakness, easy bruising, and irregular menses. Her 24 hour urinary free cortisol is elevated. Low dose dexamethaso…
- USMLE Step 1 · medium46. A 9-year-old boy presents with a 6-month history of poor linear growth, progressive headaches, and declining school performance. Vital signs show BP 108/72 mmHg, HR 88 bpm, RR 1…
- USMLE Step 1 · medium47. A 56-year-old man with a known pituitary macroadenoma presents with sudden severe frontal headache, vomiting, diplopia, and confusion. Vital signs show BP 156/92 mmHg, HR 78/min…
- USMLE Step 1 · easy48. A 32 year old woman presents 2 weeks after delivery because she has been unable to breastfeed and feels profoundly fatigued. She had severe postpartum hemorrhage requiring trans…