Organ System Pathology USMLE Step 1 Practice Question
A 48-year-old woman presents with progressive bilateral leg edema and dyspnea on exertion. Vital signs show BP 148/92 mmHg, HR 88/min, RR 18/min, temp 37°C, SpO2 98% on room air. Urinalysis reveals nephrotic-range proteinuria (8.5 g/24h). Serum albumin is 2.1 g/dL. Anti-phospholipase A2 receptor antibodies are positive. She denies hematuria. Which renal biopsy finding is most likely present?
Answer choices
- AWire-loop lesions with anti-dsDNA antibodies
- BLinear IgG deposition along the basement membrane
- CDiffuse foot process effacement with normal light microscopy
- DMesangial IgA deposition
- ESubepithelial immune complex deposits with spike and dome appearanceCorrect answer
- FSubendothelial immune complex deposits with crescent formation
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