Organ System Pathology USMLE Step 1 Practice Questions
55 board-style USMLE Step 1 questions in Pathology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 62-year-old man with a 40-year smoking history presents to the emergency department with hemoptysis, chest pain, and progressive dyspnea over 3 weeks. He reports unintentional…
- USMLE Step 1 · medium2. A 23-year-old woman presents with a 6-month history of chronic abdominal pain, nonbloody diarrhea, and 8-lb weight loss. Vital signs show HR 92/min, BP 118/76 mmHg, temperature…
- USMLE Step 1 · medium3. A 27-year-old man presents with recurrent bloody diarrhea and urgency. Vital signs show HR 92/min, BP 118/76 mmHg, RR 16/min, Temp 37.2°C. Colonoscopy reveals continuous mucosal…
- USMLE Step 1 · medium4. A 43-year-old woman with a history of gallstones presents with severe epigastric pain radiating to the back, nausea, and vomiting for 6 hours. Vital signs show BP 128/82 mmHg, H…
- USMLE Step 1 · medium5. A 24-year-old woman presents with a 6-month history of chronic diarrhea, bloating, and progressive fatigue. Vital signs show BP 118/76 mmHg, HR 88/min, RR 16/min, and temperatur…
- USMLE Step 1 · medium6. A full-term male newborn presents with abdominal distention, bilious emesis, and failure to pass meconium by 48 hours of life. Vital signs show HR 145/min, RR 42/min, BP 65/40 m…
- USMLE Step 1 · medium7. A 38-year-old man presents with burning epigastric pain that improves shortly after meals but recurs a few hours later. He has no weight loss. Upper endoscopy shows an ulcer in…
- USMLE Step 1 · medium8. A 54-year-old man with a 20-year history of alcohol use disorder presents with massive hematemesis. Vital signs show BP 92/58, HR 118, RR 22, and SpO2 98% on room air. Upper end…
- USMLE Step 1 · medium9. A 41-year-old woman presents with several months of progressive dysphagia to both solids and liquids. She also reports regurgitation of undigested food and a 4-kg weight loss. P…
- USMLE Step 1 · easy10. A 52-year-old man presents with 8 years of burning substernal chest pain that worsens after large meals and when lying flat. He has chronic nocturnal cough and occasional sour t…
- USMLE Step 1 · easy11. A 19-year-old college student presents with a 5-day history of low-grade fever, headache, dry cough, and malaise. Vital signs: temperature 38.2°C, heart rate 92/min, respiratory…
- USMLE Step 1 · medium12. A 58 year old man with alcohol use disorder is brought to the emergency department with fever, dyspnea, and productive cough. He appears toxic, and chest imaging shows dense rig…
- USMLE Step 1 · easy13. A 66-year-old man with hypertension presents with abrupt fever (39.2°C), pleuritic chest pain, productive cough with rust-colored sputum, and dyspnea. Vital signs show BP 148/92…
- USMLE Step 1 · easy14. A 54-year-old woman with septic shock from perforated diverticulitis is admitted and treated with broad-spectrum antibiotics and vasopressors. Two days later, she develops sever…
- USMLE Step 1 · medium15. A 30-week male infant born to a mother with poorly controlled gestational diabetes presents with immediate-onset nasal flaring, grunting, and intercostal retractions. Vital sign…
- USMLE Step 1 · medium16. A 29-year-old African American woman presents with a 3-week history of dry cough, fatigue, and eye pain. Physical examination reveals tender erythematous nodules on the shins an…
- USMLE Step 1 · medium17. A 41-year-old aerospace engineer presents with several months of progressive dyspnea, fatigue, and nonproductive cough. Vital signs show BP 128/82 mmHg, HR 92/min, RR 18/min, te…
- USMLE Step 1 · easy18. A 49-year-old male sandblaster presents with 3-month progressive dyspnea and dry cough. Vital signs: BP 128/82 mmHg, HR 92 bpm, RR 22/min, Temp 37.2°C, SpO2 88% on room air. Che…
- USMLE Step 1 · easy19. A 72-year-old male with 30 years of occupational asbestos exposure installing shipyard insulation presents with progressive exertional dyspnea. Vital signs show BP 138/82 mmHg,…
- USMLE Step 1 · easy20. A 67 year old man comes to the clinic because of 18 months of progressive shortness of breath and dry cough. He has never smoked and has no known occupational exposures. Examina…
- USMLE Step 1 · hard21. A 13-year-old boy presents with periorbital edema, hematuria, and declining renal function. Vital signs show BP 145/92 mmHg, HR 88 bpm, RR 16, temperature 37.2°C, SpO2 98%. Seru…
- USMLE Step 1 · medium22. A 27-year-old man presents with hemoptysis and cola-colored urine. Vital signs show BP 145/92 mmHg, HR 98 bpm, RR 22, temp 37.2°C, SpO2 94% on room air. Chest X-ray demonstrates…
- USMLE Step 1 · medium23. A 42-year-old man comes to the emergency department because of fatigue, dark urine, and reduced urine output for 1 week. Serum creatinine has risen from 1.0 mg/dL to 3.9 mg/dL i…
- USMLE Step 1 · easy24. A 57-year-old man with poorly controlled type 2 diabetes mellitus for 20 years presents with bilateral ankle edema. Vital signs: BP 156/94 mmHg, HR 88/min, RR 16/min, Temp 37°C.…