Organ System Pathology USMLE Step 1 Practice Question
A 27-year-old man presents with hemoptysis and cola-colored urine. Vital signs show BP 145/92 mmHg, HR 98 bpm, RR 22, temp 37.2°C, SpO2 94% on room air. Chest X-ray demonstrates diffuse bilateral alveolar infiltrates. Urinalysis reveals dysmorphic RBCs with RBC casts; urine protein 2.8 g/24 hours. Serum creatinine is 2.1 mg/dL. He denies recent upper respiratory infection. Which immunofluorescence pattern on renal biopsy is most likely?
Answer choices
- ALinear IgG deposition along the glomerular basement membraneCorrect answer
- BSubepithelial granular immune deposits
- CNo immune deposits on immunofluorescence
- DCongo red-positive fibrils
- EGranular mesangial IgA deposition
- FGranular IgG and C3 deposition in a capillary wall and mesangial distribution
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