Organ System Pathology USMLE Step 1 Practice Question
A 52-year-old man presents with 8 years of burning substernal chest pain that worsens after large meals and when lying flat. He has chronic nocturnal cough and occasional sour taste in his mouth. He is obese and smokes 1 pack per day. Endoscopy shows salmon-colored mucosa extending upward from the gastroesophageal junction. Biopsy demonstrates intestinal-type columnar epithelium with goblet cells. Which of the following is the most likely consequence of this patient's condition?
Answer choices
- AEsophageal rupture after retching
- BEsophageal webs associated with iron deficiency
- CFailure of lower esophageal sphincter relaxation
- DEsophageal adenocarcinomaCorrect answer
- ESquamous cell carcinoma of the upper esophagus
- FHigh-grade dysplasia within Barrett mucosa as an intermediate premalignant step
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