Organ System Pathology USMLE Step 1 Practice Question
A 57-year-old man with poorly controlled type 2 diabetes mellitus for 20 years presents with bilateral ankle edema. Vital signs: BP 156/94 mmHg, HR 88/min, RR 16/min, Temp 37°C. Urinalysis reveals heavy proteinuria (4.2 g/24h). Serum creatinine is 1.8 mg/dL. Funduscopic examination demonstrates diabetic retinopathy. Urine microscopy shows no red blood cell casts. Which renal biopsy finding is most likely present?
Answer choices
- ANodular glomerulosclerosisCorrect answer
- BSubepithelial humps
- CDiffuse podocyte foot process effacement only
- DLinear IgG deposition
- EMesangial IgA deposition
- FDiffuse diabetic glomerulosclerosis without nodule formation
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