Organ System Pathology USMLE Step 1 Practice Question
A 27-year-old man presents with recurrent bloody diarrhea and urgency. Vital signs show HR 92/min, BP 118/76 mmHg, RR 16/min, Temp 37.2°C. Colonoscopy reveals continuous mucosal inflammation starting in the rectum extending through the sigmoid colon. Laboratory studies show hemoglobin 11.2 g/dL and elevated CRP at 8.5 mg/L. He denies arthralgia or eye symptoms. Which extraintestinal manifestation is most strongly associated with this disease?
Answer choices
- APrimary sclerosing cholangitisCorrect answer
- BFistula formation and transmural inflammation
- CNoncaseating granulomas in the terminal ileum
- DOxalate kidney stones from fat malabsorption
- EMouth ulcers with skip lesions
- FAnkylosing spondylitis with HLA-B27 positivity
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