Organ System Pathology USMLE Step 1 Practice Question
A 36-year-old man with HIV presents with progressive lower extremity edema and dyspnea. Vital signs: BP 128/82 mmHg, HR 98/min, RR 20/min, Temp 37.2°C, SpO2 98% on room air. Laboratory studies reveal albumin 2.1 g/dL, proteinuria 4.2 g/24 hours, and serum creatinine 1.1 mg/dL. Urinalysis shows no hematuria. Renal biopsy demonstrates focal and segmental glomerulosclerosis with hyaline deposits on light microscopy. Which of the following is the most likely diagnosis?
Answer choices
- AMinimal change disease
- BDiabetic nephropathy
- CAmyloidosis
- DMembranous nephropathy
- EFocal segmental glomerulosclerosisCorrect answer
- FImmune complex glomerulonephritis
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