Organ System Pathology USMLE Step 1 Practice Question
A 38-year-old woman presents with progressive fatigue, unintentional weight loss, and orthostatic dizziness. She reports intense salt cravings. Vital signs show BP 92/58 mmHg, HR 102 bpm, RR 18/min, temp 37.2°C. Examination reveals diffuse hyperpigmentation of buccal mucosa and skin creases. Laboratory studies demonstrate hyponatremia (128 mEq/L), hyperkalemia (5.8 mEq/L), and low morning cortisol (3 mcg/dL). Abdominal imaging is unremarkable. Which of the following is the most likely diagnosis?
Answer choices
- ASIADH
- BPheochromocytoma
- CPrimary adrenal insufficiencyCorrect answer
- DHyperaldosteronism
- ESecondary adrenal insufficiency
- FTuberculous adrenalitis with adrenal calcifications
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