General Pathology USMLE Step 1 Practice Questions
58 board-style USMLE Step 1 questions in Pathology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard25. A 41-year-old woman presents with abnormal vaginal bleeding. Endometrial biopsy reveals adenocarcinoma with microsatellite instability on genetic testing. Her brother was diagno…
- USMLE Step 1 · medium26. A 14-year-old boy presents with multiple café-au-lait macules, axillary freckling, and cutaneous neurofibromas. Vital signs are normal (BP 118/76, HR 82, RR 16, Temp 37°C). His…
- USMLE Step 1 · hard27. A 33-year-old man with a family history of hemangioblastomas presents with hematuria. Vital signs show BP 145/92, HR 88, RR 16, temp 37°C, SpO2 98%. CT abdomen reveals a 4-cm cl…
- USMLE Step 1 · medium28. A 47-year-old man presents with a 3-month history of fatigue, early satiety, and 12-lb unintentional weight loss. Vital signs: BP 138/82, HR 102, RR 18, Temp 37.2°C, SpO2 98% on…
- USMLE Step 1 · medium29. A 58-year-old woman presents with painless generalized lymphadenopathy and fatigue. Vital signs show HR 88 bpm, BP 128/82 mmHg, temp 37.2°C, RR 16, SpO2 98%. Labs reveal hemoglo…
- USMLE Step 1 · hard30. A 17-year-old boy undergoing screening colonoscopy for familial polyposis presents with hundreds of adenomatous polyps throughout the colon. Vital signs are normal (BP 118/76, H…
- USMLE Step 1 · medium31. A 61-year-old man with metastatic pancreatic adenocarcinoma presents with profound weight loss despite consuming 2500 kcal daily. He has lost 35 pounds over 3 months, reduced mu…
- USMLE Step 1 · medium32. A 68 year old man reports the sudden appearance over 4 months of dozens of pruritic waxy brown plaques on his trunk. He also notes early satiety and unintentional weight loss. T…
- USMLE Step 1 · medium33. A 58-year-old man with history of smoking presents with acute chest pain, diaphoresis, and dyspnea. Vital signs show BP 142/88 mmHg, HR 102 bpm, RR 18, temp 37.2°C, SpO2 98% on…
- USMLE Step 1 · medium34. A 63-year-old man with hypertension (on lisinopril) undergoes colectomy for stage II colon cancer. On postoperative day 6, vital signs are stable (BP 138/82, HR 88, RR 16, temp…
- USMLE Step 1 · medium35. A 72-year-old man with ischemic cardiomyopathy presents with progressive dyspnea and bilateral lower extremity edema. Vital signs: BP 92/58, HR 104, RR 22, SpO2 88% on room air.…
- USMLE Step 1 · easy36. A 26-year-old man presents with fever (38.9°C), tachycardia (102 bpm), and a painful fluctuant nodule on the posterior neck 3 days after shaving. Vital signs show normal respira…
- USMLE Step 1 · hard37. A 2-year-old boy presents with recurrent skin and mucosal bacterial infections, delayed umbilical cord separation at 6 weeks of life, and fever (38.5°C). Vital signs show HR 110…
- USMLE Step 1 · medium38. A 19-year-old college student presents with acute bacterial meningitis. Vital signs show BP 118/76 mmHg, HR 102 bpm, RR 22/min, temperature 39.2°C, and SpO2 98% on room air. CSF…
- USMLE Step 1 · medium39. A 24-year-old woman of African ancestry presents with a progressively enlarging, raised scar at an ear-piercing site that developed over 6 months. Vital signs are stable (BP 118…
- USMLE Step 1 · medium40. A 7-year-old boy with a restrictive diet avoiding fruits and vegetables presents with gum bleeding, perifollicular hemorrhages, and delayed wound healing. Vital signs: BP 95/60,…
- USMLE Step 1 · easy41. A 42-year-old woman undergoes appendectomy for acute appendicitis. Her postoperative course is complicated by wound erythema and edema on postoperative day 5. Vital signs show H…
- USMLE Step 1 · medium42. A 27-year-old woman undergoes partial hepatectomy for living-donor liver transplantation to her brother. Three weeks postoperatively, she reports right upper quadrant fullness b…
- USMLE Step 1 · medium43. A 31-year-old woman with no prior abnormal Pap smears presents for routine cervical cancer screening. Vital signs are normal (BP 118/76, HR 78, RR 14, Temp 37°C). Pap testing re…
- USMLE Step 1 · medium44. A 54-year-old man with a 35 pack-year smoking history presents with chronic productive cough for 8 months. Vital signs: BP 138/82 mmHg, HR 88/min, RR 18/min, SpO2 98% on room ai…
- USMLE Step 1 · easy45. A 67-year-old man presents with urinary hesitancy, weak stream, and nocturia. Vital signs show BP 142/88, HR 78, RR 16, temp 37.2°C. Digital rectal examination reveals a symmetr…
- USMLE Step 1 · easy46. A 58-year-old man with poorly controlled hypertension (BP 168/102 mmHg, HR 88 bpm) for 15 years presents with exertional dyspnea. Physical examination reveals no peripheral edem…
- USMLE Step 1 · hard47. A 59 year old man with an acute myocardial infarction undergoes successful percutaneous coronary intervention 45 minutes after symptom onset. Initially his chest pain improves,…
- USMLE Step 1 · hard48. A 38 year old man employed in an industrial cleaning facility is accidentally exposed to carbon tetrachloride. Several hours later he develops right upper quadrant pain and elev…