General Pathology USMLE Step 1 Practice Question
A 41-year-old woman presents with abnormal vaginal bleeding. Endometrial biopsy reveals adenocarcinoma with microsatellite instability on genetic testing. Her brother was diagnosed with colon cancer at age 38. Vital signs are stable (BP 118/76, HR 82, RR 14, Temp 98.6°F). She denies prior chemotherapy exposure. Family history is significant for early-onset malignancies across multiple organ systems. Which gene is most likely mutated in this familial cancer syndrome?
Answer choices
- ARET
- BAPC
- CRB1
- DVHL
- EMLH1Correct answer
- FBRCA1
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