General Pathology USMLE Step 1 Practice Questions
58 board-style USMLE Step 1 questions in Pathology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. Two days after undergoing internal fixation of a displaced right femoral fracture sustained during a motor vehicle accident, a 34-year-old woman develops sudden shortness of bre…
- USMLE Step 1 · easy2. A 12-year-old boy of African descent presents with a 3-week history of progressive swelling of the right earlobe following ear piercing at a local mall 6 weeks ago. The earring…
- USMLE Step 1 · medium3. A 22-year-old woman presents with recurrent shoulder and knee dislocations. Vital signs: BP 118/76, HR 88, RR 16, Temp 37°C, SpO2 98%. Physical examination reveals hyperextensib…
- USMLE Step 1 · medium4. A 7-year-old boy presents with bleeding gums, perifollicular hemorrhages, and poor wound healing following a 6-month restrictive diet. Vital signs show HR 92/min, BP 105/68 mmHg…
- USMLE Step 1 · medium5. A 56-year-old man with a chronic lower leg ulcer undergoes surgical debridement. Vitals show BP 128/82, HR 88, RR 16, temp 37.2°C, SpO2 98%. Labs reveal albumin 3.2 g/dL and wou…
- USMLE Step 1 · medium6. A 45 year old man suffers a large contaminated laceration to the anterior shin after a farm accident. Because of tissue loss and contamination, the wound is left open and requir…
- USMLE Step 1 · medium7. A 19-year-old woman with known peanut allergy accidentally ingests a dessert containing peanuts. Within minutes, she develops diffuse urticaria, wheezing, and lightheadedness. V…
- USMLE Step 1 · medium8. A 68-year-old man with diabetes presents with pyelonephritis and gram-negative bacteremia. Despite ceftriaxone and gentamicin, he develops hypotension (BP 85/52), tachycardia (H…
- USMLE Step 1 · medium9. A 30-year-old woman experiences sudden severe dyspnea, hypotension (BP 80/50), and cyanosis during active labor. Minutes later, she develops profuse bleeding from intravenous si…
- USMLE Step 1 · medium10. A 41-year-old male scuba diver ascends rapidly following equipment malfunction. He presents with acute dyspnea, dizziness, severe shoulder and knee pain, and skin mottling. Vita…
- USMLE Step 1 · medium11. A 23-year-old man is hospitalized with a femoral shaft fracture from a motorcycle collision. Thirty-six hours later, he develops tachypnea (RR 28/min), confusion, and a petechia…
- USMLE Step 1 · medium12. A 5 year old boy is brought to the emergency department because of decreased urine output and lethargy 5 days after an episode of bloody diarrhea from undercooked beef. He is pa…
- USMLE Step 1 · medium13. A 24 year old woman undergoes emergency delivery for placental abruption. Shortly afterward she develops diffuse oozing from venipuncture sites, hypotension, and hematuria. Labo…
- USMLE Step 1 · easy14. A 61 year old man with long standing hypertension and tobacco use develops sudden severe pain and pallor of the right foot. Angiography shows acute occlusion of a popliteal arte…
- USMLE Step 1 · easy15. A 32 year old woman is 2 days postpartum after an emergency cesarean delivery. She has a history of factor V Leiden mutation and has been on prolonged bed rest. Her left calf is…
- USMLE Step 1 · easy16. A 64 year old man with severe chronic obstructive pulmonary disease develops increasing abdominal distention and lower extremity edema. Jugular venous distention and a right ven…
- USMLE Step 1 · easy17. A 69-year-old woman with rheumatic heart disease presents with progressive dyspnea and orthopnea. Vital signs: BP 148/92 mmHg, HR 108/min, RR 22/min, SpO2 92% on room air. Physi…
- USMLE Step 1 · easy18. A 76 year old man presents with exertional dyspnea and syncope. Cardiac examination reveals a late peaking systolic crescendo decrescendo murmur at the right upper sternal borde…
- USMLE Step 1 · hard19. A 49-year-old woman with metastatic breast cancer (HR 98, BP 128/82, RR 16, T 37.2°C) initially responds to doxorubicin and cyclophosphamide but develops progression at 18 month…
- USMLE Step 1 · medium20. A 55-year-old man presents with progressive fatigue and recurrent bacterial infections. Vital signs: BP 128/82, HR 92, RR 16, Temp 37.2°C, SpO2 98%. Physical examination reveals…
- USMLE Step 1 · medium21. A 58-year-old man presents with a painful violaceous scalp mass that developed 8 years after radiation therapy for brain lymphoma. Vital signs show BP 138/82, HR 88, RR 16, Temp…
- USMLE Step 1 · medium22. A 47-year-old woman presents with a 1.2-cm irregularly pigmented lesion on her upper back that has enlarged over 6 months. Vital signs are normal (BP 128/82, HR 72, RR 16, Temp…
- USMLE Step 1 · medium23. A 66-year-old male smoker presents with progressive weight loss, hyponatremia (Na+ 128 mEq/L), and cough. Chest CT reveals a 3-cm central lung mass. Vital signs show BP 138/82,…
- USMLE Step 1 · medium24. A 58-year-old woman presents with a palpable left breast mass. Vital signs show BP 128/82, HR 82, RR 16, temp 37°C, SpO2 98%. Mammography reveals a 2.3 cm irregular density with…