General Pathology USMLE Step 1 Practice Question
A 59 year old man with an acute myocardial infarction undergoes successful percutaneous coronary intervention 45 minutes after symptom onset. Initially his chest pain improves, but biomarker release rises sharply over the next several hours. Additional injury after restoration of blood flow is thought to be due in part to which of the following mechanisms?
Answer choices
- AImmediate replacement by granulation tissue
- BDecreased intracellular calcium concentration
- CUpregulation of BCL2 and inhibition of caspases
- DGeneration of oxygen derived free radicalsCorrect answer
- ESuppression of neutrophil adhesion molecules
- FIncreased production of nitric oxide by endothelial cells
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