Neurodegenerative Diseases USMLE Step 1 Practice Questions
64 board-style USMLE Step 1 questions in Neurology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 70-year-old man with hypertension presents with sudden-onset violent flinging movements of his left arm and leg. Vitals: BP 158/92 mmHg, HR 88, RR 16, temp 37.2°C, SpO2 98%. H…
- USMLE Step 1 · medium2. A 47-year-old woman presents with progressive unilateral hearing loss and tinnitus for 18 months, accompanied by occasional imbalance. Vital signs show BP 128/82, HR 78, RR 14,…
- USMLE Step 1 · hard3. A 17 year old boy is evaluated for frequent ankle sprains and difficulty running. Examination shows high arches, hammer toes, distal lower extremity weakness, decreased vibratio…
- USMLE Step 1 · hard4. A 16-year-old boy presents with slowly progressive proximal muscle weakness over 3 years but remains ambulatory and plays modified sports. His maternal uncle had a similar disor…
- USMLE Step 1 · medium5. A 4 year old boy is brought to clinic because of frequent falls and difficulty climbing stairs. Examination shows proximal lower extremity weakness, enlarged calves, and use of…
- USMLE Step 1 · hard6. A 15-year-old boy presents with progressive gait instability and recurrent falls over 2 years. Vital signs: BP 118/76, HR 92, RR 16, temp 37°C. Examination reveals pes cavus def…
- USMLE Step 1 · medium7. A 58 year old man presents with 8 months of progressive weakness in his hands and legs. He has muscle cramps and fasciculations. Examination shows atrophy of the intrinsic hand…
- USMLE Step 1 · medium8. A 52 year old man with severe alcohol use disorder is brought to the emergency department because of confusion and unsteady gait. Examination shows horizontal nystagmus and bila…
- USMLE Step 1 · hard9. A 66-year-old man presents with rapidly progressive dementia, myoclonic jerks, and gait ataxia over 4 months. Vital signs: BP 138/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Neurol…
- USMLE Step 1 · medium10. A 71-year-old woman presents with a 3-year history of progressive memory loss. She repeatedly asks the same questions, frequently misplaces objects, and has become lost while dr…
- USMLE Step 1 · easy11. A 74-year-old man presents with progressive gait difficulty over one year. His wife reports urinary incontinence and cognitive decline. Vital signs: BP 152/88, HR 78, RR 16, tem…
- USMLE Step 1 · easy12. A 56-year-old woman presents with a 6-month history of progressive frontal headaches and focal motor seizures. Vital signs show BP 138/82 mmHg, HR 88 bpm, RR 16, temp 37.2°C, Sp…
- USMLE Step 1 · medium13. An 8-year-old boy presents with progressive truncal ataxia and repeated falls over 3 months. Vital signs show HR 88/min, BP 105/68 mmHg, RR 18/min, temperature 37°C. He denies h…
- USMLE Step 1 · medium14. A 6-year-old boy presents with progressive morning headaches, vomiting, and ataxic gait for 3 weeks. Vital signs show BP 128/82 mmHg, HR 92 bpm, RR 20/min, temperature 37.2°C, S…
- USMLE Step 1 · medium15. A 41-year-old man presents with a 6-month history of focal motor seizures. Vital signs show BP 128/82 mmHg, HR 88 bpm, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. M…
- USMLE Step 1 · medium16. A 58-year-old man presents with progressive headaches, personality changes, and new-onset seizures over 3 months. Vital signs: BP 148/92 mmHg, HR 94 bpm, RR 18, Temp 37.2°C, SpO…
- USMLE Step 1 · hard17. A 4 year old girl has focal seizures and developmental delay. Examination shows a dark red vascular lesion over the forehead and upper eyelid in the distribution of the ophthalm…
- USMLE Step 1 · medium18. A 2-year-old boy presents with infantile spasms and developmental regression. Vital signs show HR 110 bpm, BP 95/58 mmHg, RR 22/min, temp 37.2°C, SpO2 98%. Physical examination…
- USMLE Step 1 · medium19. A 19-year-old woman presents with progressive bilateral hearing loss and tinnitus over 6 months. Vital signs: BP 118/76, HR 82, RR 16, Temp 37°C, SpO2 98%. MRI reveals bilateral…
- USMLE Step 1 · medium20. A 9-year-old boy presents with multiple light brown skin macules, axillary freckling, and soft cutaneous nodules on physical examination. He reports progressive difficulty in sc…
- USMLE Step 1 · medium21. A 60-year-old man with longstanding type 2 diabetes mellitus (HbA1c 8.2%) presents with sudden-onset diplopia. Vital signs: BP 148/92, HR 82, RR 16, Temp 37°C, SpO2 98%. Examina…
- USMLE Step 1 · easy22. A 36 year old pregnant woman develops sudden inability to close her left eye and drooping of the left corner of her mouth. She has hyperacusis and loss of taste on the anterior…
- USMLE Step 1 · medium23. A 57-year-old woman presents with recurrent episodes of severe, stabbing pain over the right cheek and jaw lasting seconds, triggered by teeth brushing. Vital signs: BP 128/82,…
- USMLE Step 1 · easy24. A 46-year-old man presents 3 days after resection of a right cerebellar mass. Vital signs: BP 128/82, HR 88, RR 16, Temp 37.2°C, SpO2 98%. He reports difficulty performing rapid…