Neurodegenerative Diseases USMLE Step 1 Practice Question
A 41-year-old man presents with a 6-month history of focal motor seizures. Vital signs show BP 128/82 mmHg, HR 88 bpm, RR 16/min, temperature 37.2°C, and SpO2 98% on room air. MRI demonstrates a calcified frontal lobe mass with surrounding edema. Histopathology reveals round nuclei with prominent clear halos and a delicate branching capillary network. Serum glucose is normal. He denies progressive cognitive decline. Which of the following is the most likely diagnosis?
Answer choices
- AGlioblastoma
- BEpendymoma
- CMeningioma
- DOligodendrogliomaCorrect answer
- EPilocytic astrocytoma
- FLow-grade diffuse astrocytoma (IDH-mutant, 1p/19q non-codeleted)
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