Glomerular Diseases USMLE Step 1 Practice Questions
56 board-style USMLE Step 1 questions in Nephrology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A study of a new antihypertensive drug that affects glomerular filtration rate is being conducted. Infusion of drug X causes constriction of the efferent arteriole. After infusi…
- USMLE Step 1 · medium2. A 36-year-old man comes to the physician for a 4-week history of swollen legs. He has difficulty putting on socks because of the swelling. Two years ago, he was diagnosed with s…
- USMLE Step 1 · medium3. A 42-year-old woman presents to the emergency department with a 10-day history of progressive dyspnea, hemoptysis, and productive cough. She reports no prior medical history and…
- USMLE Step 1 · hard · image4. Two weeks after undergoing an emergency cardiac catheterization for unstable angina pectoris, a 65-year-old man has decreased urinary output. He takes naproxen for osteoarthriti…
- USMLE Step 1 · hard5. A 68-year-old man with chronic kidney disease stage 3 presents with nephrotic syndrome and hypercoagulability. Serum albumin is 2.1 g/dL and urine protein exceeds 8 g/day. Kidne…
- USMLE Step 1 · medium6. A 24-year-old man with a recent upper respiratory infection presents with gross hematuria, mild hypertension, and a serum creatinine of 1.2 mg/dL. Urinalysis shows RBC casts and…
- USMLE Step 1 · medium7. A 32-year-old woman with a 2-year history of systemic lupus erythematosus presents with nephrotic syndrome and hematuria. Laboratory studies show positive ANA, low C3/C4 levels,…
- USMLE Step 1 · medium8. A 4-year-old girl with systemic lupus erythematosus presents with nephrotic syndrome (proteinuria 5.8 g/day, serum albumin 2.0 g/dL), hematuria, and declining renal function. Im…
- USMLE Step 1 · medium9. A 51-year-old woman presents to the nephrology clinic with progressive lower extremity edema and foamy urine for 3 months. She was found to have a new IgG-kappa monoclonal spike…
- USMLE Step 1 · hard10. A 56-year-old man with a 10-year history of hypertension and chronic kidney disease stage 3 presents to the emergency department with acute dyspnea, hemoptysis, and cough produc…
- USMLE Step 1 · medium11. A 32-year-old man presents with sudden onset dyspnea, hemoptysis, and hematuria. Chest X-ray shows diffuse alveolar infiltrates. ANCA testing is positive for c-ANCA with anti-PR…
- USMLE Step 1 · hard12. A 68-year-old woman with membranous nephropathy presents with nephrotic syndrome, new-onset atrial fibrillation, and dyspnea. Vital signs show BP 156/94, HR 118, RR 22, SpO2 88%…
- USMLE Step 1 · easy13. A 7-year-old boy presents 2 weeks after a streptococcal throat infection with cola-colored urine, facial edema, and hypertension (BP 130/85). Urinalysis shows hematuria with RBC…
- USMLE Step 1 · medium14. A 45-year-old woman presents to the emergency department with a 1-week history of hemoptysis, progressive dyspnea, and cola-colored urine. She denies recent infections, drug use…
- USMLE Step 1 · easy15. A 62-year-old man with a 12-year history of type 2 diabetes mellitus presents with progressive dyspnea, lower extremity edema, and weight gain over the past 3 months. Physical e…
- USMLE Step 1 · medium16. A 28-year-old woman with a 3-year history of systemic lupus erythematosus presents to the nephrology clinic for evaluation of progressive renal disease. She reports new-onset bi…
- USMLE Step 1 · easy17. A 35-year-old man presents with gross hematuria and flank pain one week after an upper respiratory infection. Vital signs: BP 128/82 mmHg, HR 88/min, RR 16/min, Temp 37.2°C, SpO…
- USMLE Step 1 · hard18. A 26-year-old man with no significant past medical history presents with acute kidney injury, hematuria with dysmorphic RBCs and RBC casts, and mild hypertension. He denies rece…
- USMLE Step 1 · medium19. A 45-year-old woman with a 10-year history of hepatitis C infection presents to the emergency department with a 2-week history of lower extremity palpable purpura, polyarthralgi…
- USMLE Step 1 · easy20. A 55-year-old man with a 10-year history of type 2 diabetes and hypertension presents with nephrotic-range proteinuria and progressive renal dysfunction. Current vitals: BP 158/…
- USMLE Step 1 · easy21. A 7-year-old boy presents with sudden-onset nephrotic syndrome. Vital signs show BP 128/82 mmHg, HR 98 bpm, RR 20/min, temp 37°C, SpO2 98% on room air. Laboratory studies reveal…
- USMLE Step 1 · medium22. A 35-year-old woman with systemic lupus erythematosus presents with edema and dyspnea. Vital signs show BP 148/92 mmHg, HR 98/min, RR 20/min, and SpO2 98% on room air. Urinalysi…
- USMLE Step 1 · medium23. A 62-year-old man with a 15-year history of type 2 diabetes mellitus presents to the clinic with progressive lower extremity edema and frothy urine over the past 3 months. He re…
- USMLE Step 1 · medium24. A 34-year-old woman presents with sudden-onset gross hematuria, periorbital edema, and hypertension (BP 158/96). Vital signs show HR 88, RR 16, temperature 37.2°C, SpO2 98% on r…