Glomerular Diseases USMLE Step 1 Practice Question
A 32-year-old man presents with sudden onset dyspnea, hemoptysis, and hematuria. Chest X-ray shows diffuse alveolar infiltrates. ANCA testing is positive for c-ANCA with anti-PR3 antibodies. Kidney biopsy shows segmental necrotizing GN with crescent formation and sparse immune deposits on immunofluorescence. Which of the following is the most likely diagnosis?
Answer choices
- APolyarteritis nodosa
- BGranulomatous polyangiitis
- CGranulomatosis with polyangiitis (GPA)Correct answer
- DEosinophilic granulomatosis with polyangiitis (EGPA)
- EMicroscopic polyangiitis
- FAnti-glomerular basement membrane disease (Anti-GBM disease)
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