Glomerular Diseases USMLE Step 1 Practice Question
A 4-year-old girl with systemic lupus erythematosus presents with nephrotic syndrome (proteinuria 5.8 g/day, serum albumin 2.0 g/dL), hematuria, and declining renal function. Immunofluorescence shows 'full house' pattern. Serum C3 and C4 are significantly depressed. Which of the following WHO lupus nephritis classes is associated with the worst long-term renal prognosis if untreated?
Answer choices
- AClass IV (diffuse proliferative)Correct answer
- BClass II (mesangial proliferative)
- CClass III/V overlap
- DClass III (focal proliferative)
- EClass V (membranous)
- FClass I (minimal change)
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