Glomerular Diseases USMLE Step 1 Practice Question
A 68-year-old man with chronic kidney disease stage 3 presents with nephrotic syndrome and hypercoagulability. Serum albumin is 2.1 g/dL and urine protein exceeds 8 g/day. Kidney biopsy shows uniform thickening of the glomerular basement membrane without inflammation. Immunofluorescence reveals IgG and C3 along the basement membrane in a granular pattern. Which of the following is the most likely diagnosis?
Answer choices
- AMembranous nephropathyCorrect answer
- BFocal segmental glomerulosclerosis
- CDiffuse proliferative glomerulonephritis
- DMinimal change disease
- EIgA nephropathy
- FMembranoproliferative glomerulonephritis
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.