Glomerular Diseases USMLE Step 1 Practice Question
A 32-year-old woman with a 2-year history of systemic lupus erythematosus presents with nephrotic syndrome and hematuria. Laboratory studies show positive ANA, low C3/C4 levels, and serologic evidence of anti-dsDNA antibodies. Kidney biopsy demonstrates subendothelial immune deposits on electron microscopy. Which of the following lupus nephritis classes is most likely?
Answer choices
- AClass V (membranous)
- BClass IV (diffuse proliferative)Correct answer
- CClass VI (advanced sclerosing)
- DClass II (mesangial proliferative)
- EClass III (focal proliferative)
- FClass I (minimal mesangial)
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