Glomerular Diseases USMLE Step 1 Practice Question
A 34-year-old woman presents with sudden-onset gross hematuria, periorbital edema, and hypertension (BP 158/96). Vital signs show HR 88, RR 16, temperature 37.2°C, SpO2 98% on room air. She denies recent pharyngitis. Serum creatinine is 1.8 mg/dL (baseline 0.8), C3 complement level is low at 32 mg/dL, and 24-hour urine protein is 2.1 g. Urinalysis reveals dysmorphic RBCs with RBC casts. Renal biopsy demonstrates subepithelial "humps" on electron microscopy. Which diagnosis best explains these findings?
Answer choices
- APost-infectious glomerulonephritisCorrect answer
- BAlport syndrome
- CMembranoproliferative glomerulonephritis
- DIgA nephropathy
- ELupus nephritis
- FDense deposit disease (C3 glomerulopathy)
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