Glomerular Diseases USMLE Step 1 Practice Question
A 35-year-old man presents with gross hematuria and flank pain one week after an upper respiratory infection. Vital signs: BP 128/82 mmHg, HR 88/min, RR 16/min, Temp 37.2°C, SpO2 98%. Urinalysis reveals RBC casts and dysmorphic RBCs; serum creatinine is 0.9 mg/dL (normal). Throat culture is negative. Kidney biopsy demonstrates predominant IgA deposition on immunofluorescence microscopy with mesangial proliferation on light microscopy. Which of the following is the most likely diagnosis?
Answer choices
- ALupus nephritis
- BPost-infectious glomerulonephritis
- CRapidly progressive glomerulonephritis
- DIgA nephropathyCorrect answer
- EAlport syndrome
- FMembranoproliferative glomerulonephritis
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