Hepatobiliary Disease USMLE Step 1 Practice Questions
54 board-style USMLE Step 1 questions in Gastroenterology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 3-week-old male infant presents to the pediatric clinic with persistent jaundice. His mother reports that despite adequate feeding every 3-4 hours with good intake, the jaundi…
- USMLE Step 1 · medium2. A 45-year-old man presents to the emergency department with 3 days of bright red blood per rectum. He denies abdominal pain or pain with bowel movements. He has a history of alc…
- USMLE Step 1 · medium3. A 45-year-old woman presents to clinic with a 10-year history of primary biliary cholangitis (PBC) diagnosed by positive anti-mitochondrial antibody and liver biopsy. She report…
- USMLE Step 1 · medium4. A 55-year-old man with a 30-year history of heavy alcohol use presents to the emergency department with abdominal distension and hematemesis. On examination, he has ascites, spi…
- USMLE Step 1 · medium5. A 42-year-old woman presents with jaundice, pruritus, and pale stools for 3 weeks. She reports right upper quadrant pain and acholic (clay-colored) stools. Ultrasound shows dila…
- USMLE Step 1 · hard6. A 48-year-old man with a 10-year history of nonalcoholic fatty liver disease complicated by cirrhosis presents to the clinic with progressive dyspnea, lower extremity edema, and…
- USMLE Step 1 · hard7. A 34-year-old woman with Wilson disease presents with acute liver failure, hemolytic anemia, and tremor. Vital signs show BP 92/58, HR 118, RR 22, temperature 37.2°C, SpO2 98% o…
- USMLE Step 1 · medium8. A 62-year-old woman with hereditary hemochromatosis and biopsy-proven cirrhosis presents for screening upper endoscopy. She reports no prior variceal bleeding or hematemesis. Vi…
- USMLE Step 1 · medium9. A 55-year-old man with alcohol-related cirrhosis presents with hematemesis. Vitals show BP 94/58 mmHg, HR 118 bpm, RR 22/min, and SpO2 98% on room air. Temperature is 36.8°C. Up…
- USMLE Step 1 · hard10. A 28-year-old woman with no significant past medical history presents to the emergency department with a 2-week history of progressive jaundice, fatigue, and abdominal discomfor…
- USMLE Step 1 · medium11. A 67-year-old male with 40-year smoking history and hepatitis C cirrhosis presents for routine screening. Vital signs: BP 128/76, HR 82, RR 16, Temp 37°C, SpO2 98%. Abdominal ul…
- USMLE Step 1 · medium12. A 38-year-old man presents to the emergency department 48 hours after undergoing ERCP with sphincterotomy for choledocholithiasis. He reports right upper quadrant pain, nausea,…
- USMLE Step 1 · medium13. A 52-year-old man with cirrhosis secondary to hepatitis C presents with acute abdominal distention, confusion, and asterixis. Vital signs show BP 118/76, HR 92, RR 18, Temp 37.2…
- USMLE Step 1 · medium14. A 45-year-old woman with a 15-year history of primary biliary cholangitis presents with progressive fatigue, pruritus, and jaundice. Laboratory studies show elevated alkaline ph…
- USMLE Step 1 · medium15. A 57-year-old man is hospitalized in shock (BP 85/52, HR 128, RR 22) following massive traumatic blood loss requiring massive transfusion. Two days later, he remains hypotensive…
- USMLE Step 1 · medium16. A 56-year-old woman with a history of cholecystitis presents with jaundice and severe pruritus for 3 days. Vital signs: BP 128/82, HR 92, RR 16, Temp 37.2°C, SpO2 98%. Laborator…
- USMLE Step 1 · medium17. A 45-year-old woman presents with constant right upper quadrant pain, fever, nausea, and vomiting for 18 hours. Vital signs show temperature 38.9°C, heart rate 102/min, blood pr…
- USMLE Step 1 · hard18. A 14-year-old boy presents with chronic hepatitis and progressive dyspnea. Vital signs show HR 92 bpm, RR 22/min, BP 118/76 mmHg, and SpO2 92% on room air. Laboratory studies re…
- USMLE Step 1 · medium19. A 23-year-old woman presents 24 hours after acetaminophen overdose with nausea, right upper quadrant pain, and jaundice. Vital signs: BP 110/68, HR 102, RR 16, Temp 37.2°C, SpO2…
- USMLE Step 1 · medium20. A 28-year-old healthcare worker presents for evaluation following a needlestick exposure. Vital signs: BP 128/82 mmHg, HR 76/min, RR 14/min, temp 37.2°C, SpO2 98%. She denies ja…
- USMLE Step 1 · medium21. A 49-year-old obese man with type 2 diabetes and hypertriglyceridemia presents with fatigue. Vital signs: BP 138/88 mmHg, HR 82/min, RR 14/min, temp 37°C, SpO2 98% on room air.…
- USMLE Step 1 · hard22. A 35-year-old woman with polycythemia vera presents with acute right upper quadrant pain and abdominal distension. Vital signs show BP 128/82 mmHg, HR 98/min, RR 16/min, temp 37…
- USMLE Step 1 · medium23. A 62-year-old woman presents with fever, jaundice, and right upper quadrant pain. Vital signs show BP 105/68 mmHg, HR 102 bpm, RR 20/min, temperature 38.9°C, and SpO2 98% on roo…
- USMLE Step 1 · medium24. A 34-year-old man with 8-year history of ulcerative colitis presents with progressive fatigue and jaundice. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98% on room a…