Hepatobiliary Disease USMLE Step 1 Practice Question
A 42-year-old woman presents with jaundice, pruritus, and pale stools for 3 weeks. She reports right upper quadrant pain and acholic (clay-colored) stools. Ultrasound shows dilated intrahepatic bile ducts with a mass at the porta hepatis. Laboratory studies reveal alkaline phosphatase 320 U/L, total bilirubin 8.2 mg/dL, and normal transaminases. Which of the following is the most likely diagnosis?
Answer choices
- APancreatic adenocarcinoma
- BCholangiocarcinomaCorrect answer
- CHepatic cirrhosis
- DGallstone pancreatitis
- EPrimary biliary cholangitis
- FHepatocellular carcinoma with bile duct invasion
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