Hepatobiliary Disease USMLE Step 1 Practice Question
A 28-year-old healthcare worker presents for evaluation following a needlestick exposure. Vital signs: BP 128/82 mmHg, HR 76/min, RR 14/min, temp 37.2°C, SpO2 98%. She denies jaundice, abdominal pain, and pruritus. Laboratory studies reveal positive HBsAg, positive anti-HBc IgM, negative anti-HBs, positive HBeAg, and elevated transaminases (ALT 320 U/L). Ultrasound shows no cirrhotic features. Which of the following best describes her current hepatitis B status?
Answer choices
- AResolved hepatitis B infection with immunity
- BAcute hepatitis B infection with high infectivityCorrect answer
- CChronic hepatitis B with low infectivity
- DWindow period of hepatitis B infection
- EVaccinated against hepatitis B
- FOccult hepatitis B infection with integration into host DNA
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