Hepatobiliary Disease USMLE Step 1 Practice Question
A 49-year-old obese man with type 2 diabetes and hypertriglyceridemia presents with fatigue. Vital signs: BP 138/88 mmHg, HR 82/min, RR 14/min, temp 37°C, SpO2 98% on room air. He denies alcohol use. Laboratory studies show AST 68 U/L, ALT 94 U/L, triglycerides 450 mg/dL; abdominal ultrasound demonstrates hepatomegaly with increased echogenicity. Which of the following is the most likely diagnosis?
Answer choices
- ANonalcoholic fatty liver diseaseCorrect answer
- BWilson disease
- CPrimary biliary cholangitis
- DAcute viral hepatitis B
- EPrimary sclerosing cholangitis
- FAlcoholic steatohepatitis
See the full explanation
Get the correct-answer rationale, why each distractor is wrong, the underlying mechanism, and high-yield associations — plus adaptive practice that targets your weak areas — with a free MedBoardPRO account.