Hematologic Malignancies USMLE Step 1 Practice Questions
55 board-style USMLE Step 1 questions in Hematology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · hard1. A 68-year-old man presents to his hematologist for routine follow-up of chronic lymphocytic leukemia diagnosed 12 years ago. He remains asymptomatic with no fever, night sweats,…
- USMLE Step 1 · medium2. A 32-year-old man presents to the emergency department with a 2-week history of progressive fatigue, petechiae, and left upper quadrant abdominal pain. He denies fever, night sw…
- USMLE Step 1 · medium3. A 45-year-old woman presents with painless lymphadenopathy and night sweats for 2 months. Physical exam reveals supraclavicular and mediastinal lymph node enlargement. Chest X-r…
- USMLE Step 1 · easy4. A 67-year-old man presents to the emergency department with progressive fatigue, bone pain, and recurrent infections over 3 months. His wife notes he has become increasingly con…
- USMLE Step 1 · medium5. A 45-year-old man presents with a 2-week history of rapidly enlarging jaw swelling, fever, night sweats, and abdominal pain. Temperature is 38.5°C, heart rate 105/min. Physical…
- USMLE Step 1 · easy6. A 65-year-old man presents with fatigue and is found to have WBC 12,500/μL on routine labs, with 70% small, mature-appearing lymphocytes. Flow cytometry demonstrates CD5+, CD19+…
- USMLE Step 1 · hard7. A 28-year-old man with no prior medical history presents with acute abdominal pain and vomiting for 3 days. Vital signs show BP 128/82, HR 104, RR 18, temp 37.8°C, SpO2 98% on r…
- USMLE Step 1 · medium8. A 52-year-old man presents to his primary care physician with a 3-month history of progressive fatigue and persistent lower back pain. He denies fever, weight loss, or night swe…
- USMLE Step 1 · medium9. A 34-year-old woman presents with painless swelling of the right axilla. Biopsy shows lymphoid proliferation with CD4+ T cells predominating and sparse neoplastic cells expressi…
- USMLE Step 1 · hard10. A 52-year-old man with a 10-year history of hepatitis C presents to the clinic with a 3-month history of fever, night sweats, and unintentional weight loss of 8 pounds. On physi…
- USMLE Step 1 · medium11. A 64-year-old woman with a 30-year history of smoking presents with hemoptysis and a right lower lobe nodule on chest CT. She has palpable lymphadenopathy in the right axilla. E…
- USMLE Step 1 · hard12. A 58-year-old man presents to the emergency department with abdominal pain, jaundice, and early satiety. He has a history of hepatitis C cirrhosis complicated by portal hyperten…
- USMLE Step 1 · medium13. A 72-year-old man presents to the emergency department with a 3-day history of epistaxis, bleeding gums, and spontaneous bruising. He was started on warfarin 1 week ago for newl…
- USMLE Step 1 · medium14. A 28-year-old man presents to the emergency department with a 2-week history of fever, drenching night sweats, and unintentional 8-pound weight loss. Physical examination reveal…
- USMLE Step 1 · easy15. A 45-year-old woman presents with progressive fatigue and early satiety. Vital signs: BP 128/82, HR 102, RR 18, Temp 37.2°C, SpO2 98%. Physical exam reveals massive splenomegaly…
- USMLE Step 1 · hard16. A 68-year-old man with a 20 pack-year smoking history presents with hemoptysis, dyspnea, and constitutional symptoms. Chest imaging reveals a left upper lobe mass with mediastin…
- USMLE Step 1 · easy17. A 35-year-old woman presents to her primary care physician for evaluation of incidental mediastinal and hilar lymphadenopathy discovered on chest imaging obtained for unrelated…
- USMLE Step 1 · easy18. A 62-year-old man presents with progressive fatigue, bone pain, and recurrent infections. Vital signs show BP 138/82, HR 92, RR 18, temperature 37.2°C, SpO2 98% on room air. Lab…
- USMLE Step 1 · medium19. A 10-year-old boy presents to the emergency department with a 3-week history of progressive jaw swelling and pain. His mother reports he has had fever (38.2°C) and appears fatig…
- USMLE Step 1 · hard20. A 65-year-old man with a 10-year history of hepatitis C infection presents to clinic with progressive fatigue and lower extremity purpura for 2 months. Physical examination reve…
- USMLE Step 1 · hard21. A 42-year-old woman presents to the emergency department with progressive fatigue over 3 months and severe lower back pain unresponsive to NSAIDs. She reports no weight loss, fe…
- USMLE Step 1 · medium22. A 28-year-old man presents to the emergency department with severe abdominal pain, high fever (39.2°C), and tachycardia (HR 118/min). He reports a 2-week history of progressive…
- USMLE Step 1 · hard23. A 48-year-old man presents with fever (38.9°C), productive cough, and dyspnea. Examination reveals left lower lobe consolidation on chest X-ray. Vital signs show BP 138/82, HR 1…
- USMLE Step 1 · medium24. A 67-year-old man presents with progressive fatigue, unintentional weight loss, and early satiety. Vital signs show BP 138/82, HR 92, RR 18, temp 37.2°C, SpO2 98% on room air. E…