Hematologic Malignancies USMLE Step 1 Practice Question
A 62-year-old man presents with progressive fatigue, bone pain, and recurrent infections. Vital signs show BP 138/82, HR 92, RR 18, temperature 37.2°C, SpO2 98% on room air. Laboratory studies reveal hemoglobin 8.2 g/dL, creatinine 2.1 mg/dL, serum calcium 11.5 mg/dL, and an M-spike on serum protein electrophoresis. Bone marrow biopsy demonstrates 35% clonal plasma cells. Urinalysis shows no proteinuria. Which of the following is the most likely diagnosis?
Answer choices
- AAcute myeloid leukemia
- BLight chain disease
- CChronic lymphocytic leukemia
- DWaldenström macroglobulinemia
- EMultiple myelomaCorrect answer
- FPrimary amyloidosis (AL amyloidosis)
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