Hematologic Malignancies USMLE Step 1 Practice Question
A 45-year-old woman presents with painless lymphadenopathy and night sweats for 2 months. Physical exam reveals supraclavicular and mediastinal lymph node enlargement. Chest X-ray shows a widened mediastinum. Lymph node biopsy demonstrates Reed-Sternberg cells with CD30+ and CD15+ immunophenotype, with CD45 negative. Which of the following is the most likely diagnosis?
Answer choices
- AHodgkin lymphoma, nodular sclerosis subtypeCorrect answer
- BDiffuse large B-cell lymphoma
- CPrimary mediastinal B-cell lymphoma
- DPeripheral T-cell lymphoma
- EBurkitt lymphoma
- FHodgkin lymphoma, lymphocyte-rich classical subtype
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