Hematologic Malignancies USMLE Step 1 Practice Question
A 28-year-old man presents to the emergency department with severe abdominal pain, high fever (39.2°C), and tachycardia (HR 118/min). He reports a 2-week history of progressive fatigue and night sweats but denies recent infections or chemotherapy. Physical examination reveals splenomegaly and abdominal tenderness. Laboratory studies show: WBC 45,000/μL with 85% blasts
Hemoglobin 10.2 g/dL
Platelets 95,000/μL
LDH 3,200 U/L
Uric acid 8.9 mg/dL
Creatinine 2.1 mg/dL (baseline 0.9 mg/dL)
Phosphate 5.2 mg/dL (normal 2.5-4.5) CT abdomen shows a rapidly enlarging abdominal mass. Tumor lysis labs are concerning. Which of the following is the most likely diagnosis?
Answer choices
- AAcute lymphoblastic leukemia
- BBurkitt lymphoma with leukemic presentationCorrect answer
- CAcute myeloid leukemia
- DAcute promyelocytic leukemia (APL)
- EChronic myeloid leukemia in myeloid blast crisis
- FLymphoblastic lymphoma with secondary leukemia
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