Hematologic Malignancies USMLE Step 1 Practice Question
A 28-year-old man with no prior medical history presents with acute abdominal pain and vomiting for 3 days. Vital signs show BP 128/82, HR 104, RR 18, temp 37.8°C, SpO2 98% on room air. CT reveals a large anterior mediastinal mass and abdominal lymphadenopathy. Serum LDH is markedly elevated at 890 U/L; CBC shows normal hemoglobin. Lymph node biopsy demonstrates large cells expressing CD30 and CD20. Which diagnosis best fits this presentation?
Answer choices
- ABurkitt lymphoma
- BLymphoblastic lymphoma
- CClassical diffuse large B-cell lymphoma
- DPrimary mediastinal B-cell lymphomaCorrect answer
- EHodgkin lymphoma
- FMediastinal seminoma with paraneoplastic lymphadenopathy
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