Demyelinating Diseases USMLE Step 1 Practice Questions
65 board-style USMLE Step 1 questions in Neurology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 Ā· hard25. A 52-year-old man with primary progressive MS on natalizumab for 2 years develops progressive weakness and cognitive decline. New brain MRI shows multiple cavitary white matterā¦
- USMLE Step 1 Ā· medium26. A 29-year-old woman presents with history of optic neuritis. Vital signs are stable (BP 118/76, HR 78, RR 14, Temp 37Ā°C, SpO2 98%). Brain MRI reveals one T2 hyperintense perivenā¦
- USMLE Step 1 Ā· hard27. A 40-year-old man presents with acute loss of consciousness, seizures, and multiple multifocal ring-enhancing lesions on brain MRI. CSF reveals lymphocytic pleocytosis with negaā¦
- USMLE Step 1 Ā· easy28. A 31-year-old woman with recently diagnosed relapsing-remitting MS presents for discussion of disease-modifying therapy. Her vital signs are stable (BP 118/76, HR 82, RR 16, Temā¦
- USMLE Step 1 Ā· hard29. A 45-year-old woman with multiple sclerosis on interferon-beta presents with progressive cognitive decline, gait disturbance, and blurred vision over 2 months. Vital signs: BP 1ā¦
- USMLE Step 1 Ā· hard30. A 19-year-old man with no prior neurological history experiences acute onset of paresthesias in both legs, progressive weakness, and urinary retention over 24 hours. MRI shows Tā¦
- USMLE Step 1 Ā· medium31. A 26-year-old woman presents with diplopia, dysarthria, and dysdiadochokinesia one week after a viral illness. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2Ā°C, SpO2 98%. Brainā¦
- USMLE Step 1 Ā· easy32. A 42-year-old woman with a 10-year history of relapsing-remitting MS presents with worsening cognitive impairment and progressive gait ataxia. Vital signs: BP 118/76, HR 88, RRā¦
- USMLE Step 1 Ā· medium33. A 28-year-old man presents with acute bilateral leg paralysis, urinary retention, and acute lower back pain following lower back sensory loss. Vital signs: BP 128/82 mmHg, HR 92ā¦
- USMLE Step 1 Ā· medium34. A 34-year-old woman presents with acute vision loss in her left eye and retro-orbital pain on eye movement. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2Ā°C, SpO2 98%. Examinatā¦
- USMLE Step 1 Ā· medium35. A 37-year-old man with recently diagnosed MS experiences sudden visual blurring in one eye with pain on upgaze. Neurological exam reveals an afferent pupillary defect and decreaā¦
- USMLE Step 1 Ā· easy36. A 26-year-old woman with no prior neurological disease presents with acute bilateral leg weakness and numbness. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2Ā°C, SpO2 98%. Spinā¦
- USMLE Step 1 Ā· medium37. A 33-year-old woman with relapsing-remitting MS on natalizumab therapy presents with progressive cognitive decline and personality changes over 3 months. Vital signs: BP 118/76,ā¦
- USMLE Step 1 Ā· medium38. A 52-year-old man presents with progressive lower extremity weakness, spasticity, and hyperreflexia over 3 months. Vital signs: BP 138/82, HR 88, RR 16, Temp 37.2Ā°C, SpO2 98% onā¦
- USMLE Step 1 Ā· hard39. A 45-year-old woman with systemic lupus erythematosus presents with acute confusion, hallucinations, and transient focal motor deficits. Vital signs: BP 148/92, HR 102, RR 20, Tā¦
- USMLE Step 1 Ā· medium40. A 7-year-old girl presents with fever (39.2Ā°C), headache, and generalized tonic-clonic seizures. Vital signs show HR 110/min, RR 22/min, BP 105/68 mmHg, SpO2 98% on room air. MRā¦
- USMLE Step 1 Ā· easy41. A 19-year-old boy develops acute ascending weakness in all four limbs and dyspnea over 24 hours following a viral upper respiratory infection. Vital signs: BP 118/76, HR 102, RRā¦
- USMLE Step 1 Ā· medium42. A 41-year-old woman presents with acute paraplegia and a sensory level at T8. Two weeks later, she develops bilateral optic neuritis. Vital signs show BP 128/82, HR 88, RR 16, tā¦
- USMLE Step 1 Ā· medium43. A 28-year-old man with multiple sclerosis on interferon-beta therapy for 3 years presents with progressive encephalopathy, confusion, and ataxia over 2 months. Vital signs: BP 1ā¦
- USMLE Step 1 Ā· hard44. A 29-year-old woman with newly diagnosed multiple sclerosis is started on natalizumab. After 14 months of treatment, she develops progressive confusion, memory loss, and gait diā¦
- USMLE Step 1 Ā· hard45. A 24-year-old man presents with 5-day progressive fever (38.9Ā°C), headache, and altered mental status. Vital signs show HR 102, BP 128/76, RR 18, SpO2 98% on room air. Brain MRIā¦
- USMLE Step 1 Ā· medium46. A 33-year-old woman with MOG antibody-positive serology presents with her third episode of optic neuritis in 18 months. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2Ā°C, SpO2 9ā¦
- USMLE Step 1 Ā· easy47. A 45-year-old man with a 15-year history of relapsing-remitting multiple sclerosis presents with progressive leg weakness and cognitive decline over the past 2 years without disā¦
- USMLE Step 1 Ā· hard48. A 26-year-old woman with recent MS diagnosis presents with acute vision loss, optic nerve swelling on fundoscopy, and transverse myelitis. Vital signs: BP 118/76, HR 88, RR 16,ā¦