Demyelinating Diseases USMLE Step 1 Practice Question
A 33-year-old woman with MOG antibody-positive serology presents with her third episode of optic neuritis in 18 months. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. Each episode has recovered partially with cumulative residual vision loss. Brain MRI demonstrates minimal white matter involvement with no corpus callosum lesions. She denies recent infections or systemic symptoms. Which diagnosis best explains her recurrent demyelinating episodes?
Answer choices
- AAcute disseminated encephalomyelitis
- BMOG-associated demyelinating diseaseCorrect answer
- CNeuromyelitis optica spectrum disorder
- DFunctional visual loss
- EMultiple sclerosis
- FChronic inflammatory demyelinating polyneuropathy
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