Demyelinating Diseases USMLE Step 1 Practice Question
A 45-year-old woman with systemic lupus erythematosus presents with acute confusion, hallucinations, and transient focal motor deficits. Vital signs: BP 148/92, HR 102, RR 20, Temp 37.8°C, SpO2 98% on room air. Brain MRI reveals multiple white matter lesions. CSF analysis demonstrates lymphocytic pleocytosis with normal glucose levels. Serum antiphospholipid antibodies are positive. She denies fever or recent infections. Which of the following is the most likely diagnosis?
Answer choices
- ACNS lupus vasculitis
- BThrombotic thrombocytopenic purpura
- CSecondary progressive MS
- DDemyelinating disease associated with SLECorrect answer
- EAntiphospholipid antibody-induced stroke
- FCNS lymphoma secondary to immunosuppression
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