Demyelinating Diseases USMLE Step 1 Practice Questions
65 board-style USMLE Step 1 questions in Neurology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium49. A 19-year-old man presents with acute paraplegia and loss of pain/temperature sensation at the T10 level; vibration sense is preserved. Vital signs: BP 118/76, HR 88, RR 16, Tem…
- USMLE Step 1 · hard50. A 31-year-old woman with multiple sclerosis on interferon-beta therapy presents with progressive confusion, cognitive decline, and behavioral changes over 4 weeks. Vital signs:…
- USMLE Step 1 · medium51. A 42-year-old woman presents with severe dysarthria, diplopia, and ataxia that worsened over 3 weeks. She reports heat sensitivity and fatigue. Brain MRI shows multiple T2/FLAIR…
- USMLE Step 1 · medium52. A 28-year-old man develops acute paraplegia and urinary retention over 12 hours. He reports back pain and recent upper respiratory infection. Spinal MRI shows a T2 hyperintense…
- USMLE Step 1 · medium53. A 34-year-old woman presents with sudden vision loss in her right eye over 2 days. She describes pain with eye movement and a central scotoma on visual field testing. Ophthalmos…
- USMLE Step 1 · medium54. A 67-year-old man with a history of terminal ileal resection presents with progressive numbness in his feet and gait instability over 3 months. Vital signs: BP 138/82, HR 88, RR…
- USMLE Step 1 · hard55. An 8-year-old boy presents with declining school performance, progressive spasticity, and hyperpigmentation over 6 months. He experiences recurrent vomiting and exhibits adducte…
- USMLE Step 1 · easy56. A 27-year-old man presents with progressive paresthesias in his feet 1 week after acute gastroenteritis with Campylobacter jejuni. He now has symmetric ascending leg weakness an…
- USMLE Step 1 · medium57. A 53-year-old man with a 20-year history of alcohol use disorder presents with chronic symptomatic hyponatremia (Na+ 114 mEq/L). During hospitalization, his sodium is rapidly co…
- USMLE Step 1 · medium58. A 7-year-old boy presents with fever (39.2°C), headache, confusion, and multifocal neurologic deficits 10 days after recovery from viral upper respiratory infection. Vital signs…
- USMLE Step 1 · hard59. A 39-year-old woman with relapsing-remitting multiple sclerosis treated with natalizumab for 6 months presents with progressive left arm clumsiness, expressive aphasia, and cogn…
- USMLE Step 1 · hard60. A 35-year-old woman presents with recurrent episodes of severe bilateral vision loss and longitudinally extensive spinal cord inflammation causing paraplegia and urinary retenti…
- USMLE Step 1 · easy61. A 25-year-old woman presents with 2 days of painful vision loss in her right eye with desaturated color perception, especially red objects. Vital signs: BP 118/76, HR 88, RR 16,…
- USMLE Step 1 · medium62. A 26-year-old woman presents with recurrent episodes of limb numbness and blurred vision over the past year. Vital signs: BP 118/76, HR 82, RR 16, Temp 37.2°C, SpO2 98%. Brain a…
- USMLE Step 1 · medium63. A 30-year-old woman presents with acute-onset diplopia and gait imbalance. Vital signs: BP 118/76, HR 88, RR 16, Temp 37.2°C, SpO2 98%. On neurologic exam, leftward gaze produce…
- USMLE Step 1 · medium64. A 28-year-old woman has had three episodes over 2 years of neurologic dysfunction, including painful loss of vision in one eye, numbness of the right leg, and urinary urgency. E…
- USMLE Step 1 · medium65. A 28-year-old woman has had three episodes over 2 years of neurologic dysfunction, including painful loss of vision in one eye, numbness of the right leg, and urinary urgency. E…