Demyelinating Diseases USMLE Step 1 Practice Question
A 35-year-old woman presents with recurrent episodes of severe bilateral vision loss and longitudinally extensive spinal cord inflammation causing paraplegia and urinary retention. Vital signs show BP 128/82, HR 88, RR 16, temperature 37.2°C, and SpO2 98% on room air. Brain MRI is unremarkable. Spinal MRI demonstrates T2 hyperintensity extending over 3 vertebral segments. Serum aquaporin-4 antibody is positive. Which of the following is the most likely diagnosis?
Answer choices
- AProgressive multifocal leukoencephalopathy
- BAcute disseminated encephalomyelitis
- CTransverse myelitis
- DNeuromyelitis opticaCorrect answer
- EMultiple sclerosis
- FDevic disease with concurrent multiple sclerosis
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