Demyelinating Diseases USMLE Step 1 Practice Question
A 26-year-old woman presents with recurrent episodes of limb numbness and blurred vision over the past year. Vital signs: BP 118/76, HR 82, RR 16, Temp 37.2°C, SpO2 98%. Brain and cervical spine MRI reveal T2-hyperintense demyelinating plaques; CSF oligoclonal bands are present. She denies fever or recent infection. She takes no immunosuppressive medications. Which additional finding would most strongly support multiple sclerosis diagnosis?
Answer choices
- AJC virus reactivation
- BRapid correction of chronic hyponatremia
- CAnti aquaporin 4 antibodies
- DAlbuminocytologic dissociation
- EOligoclonal IgG bands in CSFCorrect answer
- FAnti-myelin oligodendrocyte glycoprotein antibodies in serum
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