Toxicology USMLE Step 1 Practice Questions
58 board-style USMLE Step 1 questions in Pharmacology. Each question shows the correct answer; create a free account for the full explanation and adaptive practice.
- USMLE Step 1 · medium1. A 47-year-old man is brought to the emergency department 1 hour after being found unconscious on his porch. His wife reports he was working in the garage 4 hours ago. On examina…
- USMLE Step 1 · medium2. A 47-year-old woman comes to the emergency department because of worsening pain, discoloration, and swelling of her right hand. Two days ago, she was camping outdoors in Texas w…
- USMLE Step 1 · hard3. A 33-year-old industrial worker presents with severe hand pain and erythema after a hydrofluoric acid spill. Vital signs show HR 110/min, BP 138/88 mmHg, RR 20/min. Serum calciu…
- USMLE Step 1 · hard4. A 42-year-old man presents with severe vomiting and diarrhea 6 hours after consuming foraged wild mushrooms. He initially improves but returns 2 days later with jaundice, abdomi…
- USMLE Step 1 · medium5. A 27-year-old man presents to the emergency department with severe muscle cramps, abdominal rigidity, diaphoresis, and hypertension (BP 168/102 mmHg, HR 118/min) after sustainin…
- USMLE Step 1 · hard6. A 47-year-old woman with myasthenia gravis self-increased her pyridostigmine dose. She now presents with BP 138/82, HR 108, RR 18, temp 37.2°C, SpO2 98% on room air. She reports…
- USMLE Step 1 · hard7. A 59-year-old man receiving high-dose nitroprusside for hypertensive emergency (BP 210/120 mmHg, HR 102, RR 18, SpO2 98% on room air) becomes progressively confused over 6 hours…
- USMLE Step 1 · hard8. A 38-year-old woman undergoes peripheral nerve block before surgery. Minutes after injection, she develops circumoral numbness, tinnitus, and generalized seizures followed by ve…
- USMLE Step 1 · easy9. A 31-year-old man with opioid use disorder abruptly discontinues heroin. Two days later, he presents with piloerection, rhinorrhea, lacrimation, abdominal cramping, and yawning.…
- USMLE Step 1 · hard10. A 21-year-old woman presents to the ED confused and agitated 3 hours after taking MDMA at a nightclub. Vital signs show temperature 39.2°C, heart rate 128/min, blood pressure 14…
- USMLE Step 1 · medium11. A 32-year-old man presents to the emergency department with acute chest pain, severe agitation, and mydriasis after cocaine use. Vital signs show BP 185/110 mmHg, HR 128/min, RR…
- USMLE Step 1 · medium12. A 28-year-old woman with type 1 diabetes accidentally injects 100 units of rapid-acting insulin instead of her usual 10-unit dose. She now presents diaphoretic, confused, and tr…
- USMLE Step 1 · medium13. A 4-year-old boy is brought to the emergency department with lethargy and diaphoresis after ingesting his grandmother's diabetes medication. Vital signs: BP 90/55, HR 128, RR 22…
- USMLE Step 1 · hard14. A 67-year-old man with severe COPD presents with vomiting, tremor, and palpitations. Vital signs show HR 128/min, BP 148/92, RR 22/min, temperature 37.2°C, and SpO2 92% on home…
- USMLE Step 1 · hard15. A 56-year-old woman with bipolar disorder on lithium presents with coarse tremor, ataxia, and confusion after 3 days of vomiting and diarrhea. Vital signs show BP 108/72, HR 102…
- USMLE Step 1 · medium16. A 49-year-old man with severe alcohol use disorder presents with confusion, ataxia, and poor oral intake for 3 days. Vitals: BP 118/76, HR 102, RR 16, Temp 37.2°C, SpO2 98%. Lab…
- USMLE Step 1 · medium17. A 52-year-old man with alcohol use disorder presents with acute pancreatitis. Forty-eight hours after admission, he develops tremors, anxiety, and diaphoresis. Vital signs show…
- USMLE Step 1 · easy18. A 45-year-old man with alcohol use disorder presents with acute flushing, throbbing headache, nausea, palpitations, and diaphoresis 15 minutes after consuming one beer. Vital si…
- USMLE Step 1 · medium19. A 43-year-old woman with breast cancer receiving doxorubicin presents with progressive dyspnea and fatigue. Vital signs show BP 128/82 mmHg, HR 102 bpm, RR 18/min, and SpO2 98%…
- USMLE Step 1 · medium20. A 54-year-old woman with lymphoma receiving high-dose cyclophosphamide presents with dysuria and gross hematuria. Vital signs show BP 128/82, HR 92, RR 18, Temp 37.2°C, SpO2 98%…
- USMLE Step 1 · medium21. A 48-year-old woman with rheumatoid arthritis presents with severe oral ulcers, dysphagia, and fatigue. She mistakenly took methotrexate 25 mg daily for 2 weeks instead of weekl…
- USMLE Step 1 · hard22. A 32-year-old man on isoniazid for latent tuberculosis presents after intentionally ingesting an unknown quantity of his medications. He is febrile (38.5°C), tachycardic (118 bp…
- USMLE Step 1 · medium23. A 61-year-old man presents to the emergency department after intentional ingestion of sustained-release verapamil tablets. Vital signs show BP 78/52 mmHg, HR 38/min, RR 16/min,…
- USMLE Step 1 · medium24. A 19-year-old woman presents to the emergency department after intentional propranolol overdose. Vital signs show BP 78/52 mmHg, HR 38 bpm, RR 16, temperature 37°C, and SpO2 98%…