Toxicology USMLE Step 1 Practice Question
A 54-year-old woman with lymphoma receiving high-dose cyclophosphamide presents with dysuria and gross hematuria. Vital signs show BP 128/82, HR 92, RR 18, Temp 37.2°C, SpO2 98% on room air. Urinalysis reveals 50 RBCs/hpf and blood 3+ with negative nitrites and leukocyte esterase. Cystoscopy demonstrates hemorrhagic cystitis. She denies fever or flank pain. Which medication reduces this chemotherapy-induced bladder toxicity when given prophylactically?
Answer choices
- AAmifostine
- BMesnaCorrect answer
- CFilgrastim
- DDexrazoxane
- ELeucovorin
- FAllopurinol
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